Monday, December 23, 2013

Galantamine Back In Stock

I've had a lot of calls and emails about restocking Galantamine. I heard you and it's happened. Product will be shipping to customers approx Jan 15th. 4mg x 90 tablets per bottle. As you've come to expect from Relentless Improvement, this is a medical-grade, ultra pure material. You can pre-order now at this link: Galantamine.

Galantamine is a naturally occurring plant extract that has been shown to support and maintain cognitive function, particularly among seniors.

Galantamine helps sustain balanced levels and healthy functioning of acetylcholine, a key neurotransmitter, which is important for optimal memory and cognitive functioning.

Found in nature in the Shorttube Lycoris Lily plant, the research on galantamine has much positive and compelling research.

Thursday, November 28, 2013

Cafe Perla Coffee - Now Available. 100% Arabica beans. Single-origin. Organic. Direct-trade. Sustainably harvested. Delicious!

Cafe Perla Coffee now available in the Relentless Improvement online store.

Pete! What are you doing selling coffee? Well, as crazy as it might seem at first thought, it's actually not. Coffee has a variety of health benefits, especially for support of cognition and cognitive associated issues. I drink coffee several times per day and can't imagine not having my daily cup.

I've come to know a local boutique coffee business, Apropos International, who's owner David Madsen travels to Peru to locate and work directly with coffee growers that employ organic and sustainable methods of growing their coffee.

Apropos International Cafe Perla Coffee is Farm to Cup coffee, based on the principles of direct-trade with small local farmers: transparency, sustainability and fairness. The coffee is high altitude grown, 5000-7500', 100% Arabica.

The storage and processing of the beans is done in Reno Nevada, where the low humidity, high-desert air precludes the growth of mycological organisms (fungi/molds/mildews, yuck!). Cafe Perla Coffee begins with clean, dry beans! By the way- Reno is 450 miles north of Las Vegas, please don't confuse the two :-)

The coffee for sale on our website is freshly ground and stored in climate controlled conditions, ensuring you a delicious cup of full-bodied coffee.

Try some today. Order your choice of 12oz light, medium or dark roast ground coffee at this link: Cafe Perla Coffee.

Monday, November 04, 2013

Why I Provide Public Certificates of Analysis- "DNA tests show that many pills labeled as healing herbs are little more than powdered rice and weeds"

Why I Provide Public Certificates of Analysis- "DNA tests show that many pills labeled as healing herbs are little more than powdered rice and weeds". A thought-provoking article today in the New York Times: Herbal Supplements Are often Not What They Seem.

Some quotes: "Using a test called DNA barcoding, a kind of genetic fingerprinting that has also been used to help uncover labeling fraud in the commercial seafood industry, Canadian researchers tested 44 bottles of popular supplements sold by 12 companies. They found that many were not what they claimed to be, and that pills labeled as popular herbs were often diluted — or replaced entirely — by cheap fillers like soybean, wheat and rice. "


"The findings, published in the journal BMC Medicine, follow a number of smaller studies conducted in recent years that have suggested a sizable percentage of herbal products are not what they purport to be. But because the latest findings are backed by DNA testing, they offer perhaps the most credible evidence to date of adulteration, contamination and mislabeling in the medicinal supplement industry, a rapidly growing area of alternative  that includes an estimated 29,000 herbal products and substances sold throughout North America. "

With one exception (EgCG), "DNA Barcoding" is not an applicable testing method for the Relentless Improvement line of products (they are not herbal), however other very specific test methods are employed which provide you the proof of quality you deserve.

Since 2005, Relentless Improvement has provided customers with public Certificates of Analysis (see here) on all Relentless Improvement brand finished products, with testing conducted by USA based, FDA registered analytical laboratories. These CoA's are tied by lot number to the product currently shipping to customers. These CoA's are a customers ultimate and only assurance of product quality, purity and sterility.

For those of you seeking the highest documented quality of the finished product, with full public disclosure, Relentless Improvement Nutritional Supplements is, and has been, the world-wide gold standard by which all others are judged.

Yes, I am proud of that :-)

Thursday, October 31, 2013

Relentless Improvement EgCG Green Tea Extract Documented Free of Pesticide Residue

Relentless Improvement EgCG Green Tea Extract now documented free of pesticide residue. This is very good news for folks using EgCG for specific health concerns, requiring higher doses every day for life. If the base material (tea leaves) originates from an area that has been treated with toxic pesticides, those harmful chemicals can carry over to the EgCG finished product.

Now, with documentation proving Relentless Improvement EgCG Green Tea Extract is pesticide residue free, customers can buy and use this product with even greater confidence. No other green tea extract in the world documents their product as I do.

View the Relentless Improvement Certificates of Analysis page now to learn more about the steps we take to assure you of a true pharmaceutical grade EgCG product. Click the EgCG link at the bottom of the page to view full testing results of the finished product, tied by lot number to the product shipped to you.

Sunday, September 29, 2013

Uterine Fibroids and EGCG (Green Tea Extract)

 Good news for women concerned about uterine fibroids. A new study on PubMed evaluates the efficacy and safety of green tea extract, specifically epigallocatechin gallate [EGCG] in a double-blinded, placebo-controlled randomized clinical trial. By the end of the study, fibroid size (volume) was reduced by 32.6% among women receiving the EGCG extract, while it increased 24.3% in the placebo group.

The women used 800 mg of green tea extract (EGCG) or a placebo, taken after meals, daily for 4 months. In the placebo group (n = 11), fibroid volume increased (24.3%) over the study period; however, patients randomized to green tea extract (n = 22, 800 mg/day) treatment showed significant reduction in total UF volume. In addition, EGCG treatment significantly reduced fibroid-specific symptom severity compared to the placebo group. Anemia also significantly improved in the EGCG treatment group (anemia can occur with fibroids). No adverse effects were observed in either group.

For those choosing to use an EGCG supplement, a critical consideration is to use a documented pharmaceutical grade green tea extract standardized to a high EgCG content, low in caffeine and NOT derived via a chloroform extraction process. Furthermore it is essential that any green tea supplement be tested for the existence of contaminating heavy metals. Relentless Improvement brand Green Tea EgCG Supplement meets all of these qualifications and carries a public Certificate of Analysis of purity, sterility and claimed EGCG content. 

EGCG shows promise as a safe and effective therapeutic agent for women with symptomatic UFs. Such a simple, inexpensive, and orally administered therapy can improve women's health globally.

Taking a green tea extract is not advisable for women who may be conceiving or are pregnant, due to increased risk of birth defects (see Concerns and Cautions).

Monday, April 15, 2013

Carnitine: Terrible Toxin? Or Necessary Nutrient? Inform Yourself With Facts and Avoid Bombastic BS! :-)

From our friends at Geronova Research :

Hello all,

By now many of you may have seen the article or heard the news regarding meat consumption and heart disease risk. It also discussed the substance carnitine, found in meat, and also in many nutritional supplement products. I have received many questions on this study, so thought it appropriate to send out an email with Dr. David Brady's official response.

From what I can conclude at this point, it is not carnitine that is the problem. It is the gut flora that produce TMAO and can potentially utilize carnitine and other substrates.

There are many questions to be answered. For example, what type of gut microbiota will produce TMAO from meat and other foods? By the way, carnitine is not just found in red meat, it is also found in chicken, fish, and dairy products. Carnitine has been studied extensively because it is so important to energy production and is a well-tolerated and generally safe therapeutic agent.

I certainly will not stop eating foods that contain carnitine and give up carnitine supplements based on this study...too many variables and questions unanswered. And there is much more research showing the benefits of carnitine!

"Calm Down About Meat and Carnitine Folks!
David M. Brady, ND, CCN, DACBN

By now many of you may have seen the article in the NY Times and elsewhere regarding meat consumption and heart disease risk. It also discussed the substance carnitine, found in meat, and also in many nutritional supplement products. This is very interesting research, but not in the least surprising. This is a matter of variable GI microbiota (the bugs that grow and live inside human’s intestines), and their subsequent metabalome (chemicals and substances produced by these microbes), in people chronically consuming different diets. The reality is that people who very commonly eat meat simply develop a different composition of the GI bacteria than those who eat vegan or vegetarian, for instance, or those who meat less frequently. While it has been well‐established statistically that those who consume red meat have a somewhat higher statistical incidence of cardiovascular events, it also does not seem logical in many ways that this is all
connected to the fats and cholesterol in the meat, or even the high‐levels of the pro‐inflammatory arachadonic acid in the meat due to corn feeding of the animals, although those are certainly contributory. The issue of specific microbes commonly present in the GI environment only in frequent meat eaters metabolizing this dietary substrate (meat) in a novel manner which liberates a problematic compound, in this case TMAO, is very plausible and I have no specific reason to doubt the specific findings of this latest research. That TMAO can also derive from the carnitine component of the meat is also certainly plausible.

However, we need to be very careful how we interpret such narrowly focused research in the greater context. How the media draws conclusions and spins the take‐away message from such research is very deceiving and can misinform and unnecessarily scare the public and consumers all for the sake of a good story, or simply due to a lack of understanding of the limitations of making such broad conclusions based on such narrow research. For instance, if you study something and find out that it has 50 beneficial properties, and then study the same compound in a different way and find something that under the right circumstances may be negative, is the substance being studied then immediately something “bad”? And if you just finished reading the one negative study, and may have had no exposure to the positive ones, you would likely come away with the impression that the substance in question is “bad”. However, in reality, virtually everything can be somewhat “good” and somewhat “bad” under certain circumstances. For instance, if you search the medical literature you will find studies of people dying from drinking water under certain circumstances, such as over‐hydration during exercise diluting blood electrolytes and causing heart failure. Do you have any plans to immediately stop drinking water? If you look at any of these issues and research paper press releases in a very narrow, reductionist and myopic manner you will OFTEN draw very reactionary and incorrect conclusions.

The facts: Carnitine is a substance manufactured in the body from the amino acids lysine and methionine, which you derive whenever you eat any proteins containing these amino acids, not just meat! In living cells, it is required for the transport of fatty acids located in the body’s cells into the mitochondria during the breakdown of lipids (fats) for the generation of energy. There are reams of quality scientific literature supporting its safe use for maintaining optimal body composition and weight loss, to support those with fatigue or energy deficiency syndromes, and even for use in patients with various kidney and cardiac diseases. That does not sound like really bad stuff to me, and if it was why would your own body make it? Perhaps the issue of carnitine is more complex than the sound bites from this recent research study press release?

See more about carnitine at:

If carnitine, or meat for that matter, is the main culprit in cardiovascular mortality how do you explain
the following?‐of‐death/coronary‐heart‐disease/by‐country/

and this:

Note that the highest meat consumption (thus carnitine consumption) are in countries like the US [120.2](80.5), Canada [94.3](66.2), Australia [115.5](60.3), Argentina [98.3](70.6), Spain [97](43.5), and New Zealand [106.4](76.5). Low meat consumption countries are India [4.4](165.8), Indonesia [11.6](150.8), Pakistan [14.7](222.9), and Bangladesh [4](203.7).

In parenthesis are the death rates per 100k from heart disease. In brackets is annual meat consumption per capita.

Clearly there is something going on much more significant than the production of a byproduct in the gut from consumption of meat/carnitine. For instance, research shows that choline consumption produces similar levels of the harmful chemical in question in this latest study (TMAO) by these bacteria. Choline is present in many vegetable products and is especially high in nuts, seeds, and grains. Will you stop eating vegetable, nuts and seeds now too?

I wonder why these researchers, and the media, chose to focus on carnitine, and thus shine a negative light on red meat and carnitine? Is there some kind of agenda or are there unknown market forces at work here, or perhaps just a good alarming story for the media to sell papers, magazines and generate web site hits? I am not sure, but there is certainly not sound and rational science behind the conclusions drawn by the media, and sadly, many of the other scientists quoted in reaction to this latest paper in Nature Medicine.

When these kinds of studies generate popular media press releases and stories that scare you about something new every other day it seems please pause and take a nice deep breath and remember that it is the preponderance of the evidence that really counts and that the story behind complex metabolic issues is often much more elaborate than any one study is able to evaluate."

Saturday, March 23, 2013

Fad supplements come and go, but research shows some materials have earned durable promise in the quest for a longer, more healthy lifespan: Curcumin, Trans-Resveratrol and five specific Calorie Restriction mimetics. There is detailed information on the three product web pages below that you can sink your teeth into if you are so inclined. Here is a snapshot description of each of the three products I recommend to be used together.

Revgenetics Micro500 Micronized Resveratrol:

* 500mg of *Micronized* Trans-Resveratrol Per Capsule
* The only micronized resveratrol in a 500mg capsule.
* Estimated up to 220% more effective over regular resveratrol supplements.
* Particle size between 1-2 microns + pharmaceutical grade = high absorption/real benefits.
* Vegetarian capsules.
* Independently tested in a United States laboratory for safety and purity.
* Very low Emodin content prevents the laxative effect of "grocery store" quality resveratrol.
* Made in the USA.

CR Mimetic Longevity Formula:

LEF has brought together the six known calorie restriction mimetics … trans-resveratrol, trans-pterostilbene, fisetin, quercetin, grape seed polyphenols, and black tea extract in one, high-potency formula.

Super Bio-Curcumin:

Curcumin is impressing scientists around the world with its remarkable multiple health benefits. Curcumin is a polyphenol present in the spice turmeric and was first used by Indians over 3,000 years ago in traditional Ayurvedic medicine. Modern science has found that curcumin has remarkable antioxidative, immunomodulatory, proapoptotic, hepatoprotective and antiangiogenic properties.

Here is my personal review: I have been using these three products for the past month, 1 capsule per day of the Super Bio-Curcumin, 2 capsules per day of the CR Mimetic Longevity Formula and 2 per day of the Revgenetics Micro500 Micronized Resveratrol (I consider the 250mg of resveratrol in the CR Mimetic to be an adjunct to the 1000mg of the Micro500 I am taking, you should adjust your dose of Micro500 based upon your personal needs). My energy level is up, I feel great, and have more endurance. No side-effects or gastrointestinal upset. And if the promising research proves true, I am investing now towards living a longer, healthier life.

Be a wise shopper: please take the time to review and understand the differences between the materials above and cheap, grocery-store quality alternatives. *Bio-availability is the key to success! Passing low-quality materials, unabsorbed by your body, is a waste of money and loss of benefits*