Saturday, June 21, 2008

Barrons Article- Polyphenols and Resveratrol Get More Publicity

An article (subscription access) in Barrons this weekend:

"Healthy Returns – How to Live Longer"
"Special Report: Retirement -- Eight things to do to live longer and minimize the aches and pains of aging." By MARY PINKOWISH

Touches on the usual things: Exercise, eat right, lose visceral fat, and then what caught my eye- "Your Choice: Eat or Drink Your Polyphenols"

Ha! I have posted many times in many places how friendly I am towards polyphenol supplements. Especially Resveratrol (and EgCG).

From her article: "Evidence has been building for 20 years that at least in some animals, extreme caloric deprivation triggers a process that curbs degenerative aging. Most people would find the amount of required caloric restriction (about 30%) too hard to maintain. But scientists have found that a chemical called resveratrol, famously present in red wine, may mimic the effects of caloric restriction.

Earlier this month, Richard Weindruch, a professor at the University of Wisconsin-Madison Institute on Aging, and colleagues published a study in the online journal PLoS One showing that resveratrol may delay aging in mice at lower doses than previously thought. "No other nutrients that I'm aware of have the ability to increase maximum life expectancy in mice. It's striking," says Weindruch. The findings, he adds, suggest that resveratrol and other polyphenol compounds "have the ability to oppose multiple aspects of aging."

Good stuff.

As always, if you choose to supplement, you must be very careful to read your labels. Purity and potency are critical. Low quality resveratrol (50% or less) contains a lot of (a byproduct of manufacture) called emodin, a powerful laxative! Relentless Improvement brand Resveratrol is a 98% extract. The emodin level is nearly undetectable.

Low quality EgCG supplements are standardized to a low percent of polyphenols. Relentless Improvement brand EgCG Green Tea Superpotent Extract is standardized to an astounding 99.31% polyphenols. And free of residual processing solvents (yuck).

Be a smart shopper and understand that quality is the most important aspect of your buying decision.

Happy Weekend-
Pete Hitesman
Relentless Improvement

Wednesday, June 04, 2008

Resveratrol In the News

More Resveratrol in the news. First this article:

"He described how his research found that mice given large doses of resveratrol "live longer, they're almost immune to the effects of obesity. They don't get diabetes, cancer, Alzheimer's as frequently. We delay the diseases of aging."

and in this study: New hints seen that red wine may slow aging

"The study is based on dosing mice with resveratrol, an ingredient of some red wines. Some scientists are already taking resveratrol in capsule form..."

Look, definitive answers on life extension (longevity) supplements are not yet available. But the fact that scientists feel confident enough that resveratrol is doing something good in their bodies to personally use it- is compelling. Personally, I use our Relentless Improvement brand high-dose high-purity 300mg per capsule resveratrol supplement at 3-5 capsules daily.

The absolute key when using a high-dose resveratrol product is low emodin (a byproduct of manufacturing, and a powerful laxative!). Relentless Improvement resveratrol is documented to be 98%+ purity and extremely low in emodin.

Bottom line: if you choose to use resveratrol as an adjunct to a healthy lifestyle of good diet and exercise, it is critical to go for quality!

Invest in an ultra-pure (98%+), very low emodin, documented (very few suppliers do independent analysis as we do) resveratrol supplement.

To your health and long life!
Pete Hitesman

Monday, June 02, 2008

Acetyl-L-Carnitine and Lipoic Acid: the New Nootropics?

Brand new study out:

"Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?"

"CONCLUSIONS: L-carnitine and alpha-lipoic acid are pleiotropic agents capable of offering neuroprotective and possibly cognitive-enhancing effects for neuropsychiatric disorders in which cognitive deficits are an integral feature."

"Preliminary controlled trials in depressed geriatric populations also suggest an antidepressant effect with acetyl-L-carnitine."

This does not surprise me at all. There is so much good research out their on the benefits of lipoic acid and Acetyl-L-Carnitine, I think you would be crazy not to incorporate both as part of a smart daily regimen.

Remember, r-lipoic acid is key, and it must be a stabilized version of the material if you want high bioavailability!