Tuesday, January 03, 2006

EGCG and CLL (Chronic Lymphocytic Leukemia) More Info

I was reminded today by a Customer of the recent press release from the Mayo Clinic regarding their ongoing trials of CLL patients using an EGCG extract (NOT green tea!).

A quote from the press release:

"A new case study by Mayo Clinic researchers provides preliminary evidence to suggest a component of green tea may lead to clinical improvement in patients with chronic lymphocytic leukemia (CLL). Findings are published online in Leukemia Research."

"In the small case study, the researchers report on four patients who appeared to have an improvement in the clinical state of their disease after starting over-the-counter products containing epigallocatechin gallate (EGCG), an extract of green tea. Three of the four patients met the standard criteria used to define a response treatment for clinical trials. These same investigators had previously shown that EGCG kills leukemia cells from patients with CLL in the test tube by interrupting the communication signals they need to survive. That study was published in Blood in 2004. "

My customer told me he heard the amount of EGCG used was 3000mg daily which would equate to 5-6 capsules per day of EGCG Max (providing 560mg total catechins per capsule).

Or about 10 capsules per day if you consider only the EGCG component of the mixed catechins. I do not know if the studies broke out EGCG from total catechins.

ECGG Max is 90 vegi-caps per bottle.

Once again, this is not a situation where you want to use an off the shelf, grocery store green tea product. Please understand the difference between a pharmaceutical grade, standardised extract and the average crap that gets sold across the counter.

Pete

Ashwagandha (Ghanda)

I just put the Ashwagandha on super special sale. Normally $19.95 for 120 vegi-caps of 750 mg, on sale for $10.95 or two or more for $9.95 ea. This product was totally over ordered, so I fired the buyer, and my loss is your gain. Expiry - 7/07 so it has a nice long shelf life.

Information below copyright and courtesy of Advanced Orthomolecular Research:

"In a double-blind trial in humans, 101 healthy men aged 50 to 59 were evaluated for various aging parameters over the course of a year. Increased red blood cell levels, greater libido, and lower erythrocyte sedimentation rate (a measure of chronic inflammation) were observed in the men who got Ashwagandha instead of the dummy pills."

and

"In another study, a mixture of sitoindosides from Ashwagandha activated the peritoneal macrophages (a kind of immune cell) in laboratory animals, increasing their mobilization and their ability to consume foreign bacteria while boosting levels of enzymes that help the body break down damaged and toxic molecules left over from the body’s metabolic process. In yet a third study, administration of Ashwagandha extract to either healthy or tumor-bearing animals was found to enhance the proliferation of immune cells and their precursors in the thymus and bone marrow, actually doubling the body’s response to either of two immunological challenges. Ashwagandha also boosted the activity of natural killer (NK) cells, and the immune cells’ ability to destroy infected and foreign cells was enhanced."

and

"Ashwagandha (Withania somnifera), the so-called “Indian ginseng,” is actually not a ginseng species at all; and while it does provide powerful support against overwhelming stress, its effects are in many ways distinct from most other adaptogenic herbs."

Once we sell down the inventory, we will set it back to regular price.

Pete