Thursday, June 29, 2006

AOR Essential Mix: Ortho-Core's Little Brother

Ortho-Core is again on world-wide backorder. We are totally sold out. No idea when we will have more in.

BUT

You have another choice and that is AOR's Essential Mix. This Multi-vitamin powder, is identical to Ortho-Core's foundational ingredients. If you find yourself out of Core, consider using Essential Mix powder. In stock, ready to ship.

I like the flavor and it works great in smoothies too.

Pete

Vitamins
Supplements

Tuesday, June 27, 2006

FDA Crackdown

On cherry farmers!

Yikes.

The average person on the street may not realize the extent we have to go to avoid making health claims for our products. Here at this link from Business Week (free page) is a fine example.

Friday, June 23, 2006

Ortho-Core Update and a Heads-Up

Of the new Ortho-Core stock arriving today, more than two-thirds is already presold (and will ship today). I expect we will (again) be sold out within a few days. AOR is sold out worldwide and it will be some weeks before more is available. If you are not already stocked up with at least a two month supply, now is the time to order.

Pete

Wednesday, June 21, 2006

Ortho-Core Update

Shipment is in USA but still has not cleared US Customs - I have advised AOR I will pay for 2nd Day Air or Overnight Air to get stock in here by Friday. Keep your fingers crossed.

My commitment to you, I will ship all pending Ortho-Core orders on the same day I receive stock. Thank you for your patience.

Sheesh.
Pete

Monday, June 19, 2006

Ortho-Core Update: Shipping Friday. Expect More Shortages

A new shipment is now in the US and pending FDA import clearance. Barring unforeseen tie-ups Ortho-Core will be back in stock and shipping this Friday.

I have set the website to allow pre-orders. I bought AOR's remaining inventory as I expect more shortages.

Pete

Friday, June 16, 2006

Follow-up to R-Lipoic Acid Discussion Paper by David A. Carlson

Follow-up to R-Lipoic Acid Discussion Paper by David A. Carlson.

There were only a small handful of questions, below is a response to them from David Carlson. Huge thanks go to David, and the GeroNova folks for making the time and effort to provide this information to us, I imagine he has some sleep to catch up on!

From David:
"As my professor used to say; "there are no stupid questions as long as you prove to me you've taken the time to explore the question yourself... otherwise you're wasting my time. If one reads the papers cited by AOR that "prove" that only RLA can alter the NADH/NAD+ ratio they might question this argument.

This was actually one of AOR's weaker contentions. If one studies the papers cited by AOR, they see that the concentration used was 0.5 mM, sustained in culture for 24 hours. Do you think you can achieve that with an AOR RLA containing product? You can't even hit this level by injection.

One of the main purposes of my paper was to provide interested parties with the tools they'd need to read the studies, consider the concentrations used in them and evaluate the likelihood of whether or not they had any in vivo relevance . This is absolutely essential in order to determine before trying to make definitive statements concerning in vivo mechanisms. This was the main problem with and the criticism of the piece by AOR. I think it is also safe to say that the anonymous AOR author has no idea how much RLA you'd have to inject to obtain a level of 0.5 mM. If you consumed RLA by the spoon full all day long you would still not see this concentration level in your tissues.

Referring to my chart you'll see that 0.5mM ~=103,000 ng/ml whereas the amount you see in plasma is ~1154 ng/ml after consumption of 1 gram of either pure RLA or R-DHLA. I've measured a "walloping" (not!) 30-40ng/ml RLA in plasma from a commercial 150 mg RLA product, so the amount used in this paper are 2475-3433 times greater than you can get from AOR's RLA.

Therefore, under real life conditions no one can say whether or not RLA can have any significant and direct effect on these ratios. There are quite complex networks within the cell to store and shuttle reducing equivalents, rather than just effluxing the R-DHLA after RLA is reduced as AOR suggested.

We also do not know how much R-DHLA itself can be taken up by the cell or how much RLA actually traverses the cytosol and gets actively transported into the mitochondria when the cell is exposed to these low concentrations. It is possible that R-DHLA can be taken up by the cell and modulate the intracellular redox status directly or through interaction with the thioredoxin and glutaredoxin systems. It is apparent that there is cross talk between the plasma redox status and the intracellular redox state although they exist on separate circuits, so our approach to modulating the plasma redox itself may be even more practically viable than trying to load your cell with so much RLA.

Regarding MCT-RALA plasma levels versus the RG, R+, R+ASTA and MG products: there is no contradiction. I did not say that R-DHLA was the ONLY way to improve plasma stability and concentrations. The levels were significantly higher than raw RLA and I believe this was due to the competitive inhibition of RLA uptake in the presence of MCFA. Unfortunately, this was originally an R&D product done for a specific international customer but it proved to have long term stability problems, as well as too low an active load of RLA to use in formulations, so we are no longer offering it. With some more development work, it could be improved upon, which is why we still had it on the website. The problem is that it was significantly more difficult and expensive to make and really offers no advantages over the other products.

David A. Carlson
Director R&D GeroNova Research
www.GeroNova.com"

Wednesday, June 14, 2006

GeroNova Discusses R-lipoic Acid and R-dihydrolipoic Acid

Click here for the full write-up which is a 522kb Adobe Acrobat download.

This is the much anticipated piece from GeroNova Research. Given the cutting edge nature of the research, there are many questions about alpha-lipoic, R-lipoic, S-lipoic and R-dihydrolipoic acids.

In a Pete's Place exclusive, one of the worlds authorities on lipoic speaks out publicly.

Blog comments are enabled - enjoy!

Foreword provided by and courtesy of GeroNova Research.

"Important Notice: The following article is technical and it is essential to understand a few basic principles of pharmacology before delving into it. Although these principles are intuitive it is essential to keep them in mind while reading.

1-The valued properties of a nutrient or medicinal substance are limited by the physical properties and stability of the substance.

2-The ability of the dosage form containing the active substance must disintegrate, dissolve and be absorbed in the body, and not be extensively metabolized by the liver.

3-The valued properties of a nutrient or medicinal substance can only be realized if they can reach significant levels within the body at various sites of action.

4-Therefore, in vitro (an artificial model that isolates particular variables) and animal models suffer severe limitations as being predictive of how a substance will behave in vivo in humans at a particular dose and for a sufficient length of time before being cleared.

5-The amount of physical substance in a tablet or capsule is far less important than the bioavailability (the amount available to living cells) of the substance.

6-Lipoic acid has been used since the mid 1950’s as a medicine or drug to treat diabetic neuropathy. The effective therapeutic doses range from 600-1200 mg/day orally or injected.

7-Lipoic acid has been recommended as dietary supplement at doses of 50-150 mg/day since the early 1990’s.

8-No one has carefully elucidated the relationships between the doses and responses of either the supplemental dose or therapeutic dose or the differences between quick release and sustained release ALA/RLA products.

9-GeroNova has been unable to measure any significant effects at the 50-150 mg dose of ALA or RLA and defines the supplemental dose as containing up to 300mg of RLA and its naturally occurring redox partner R-DHLA.

10- GeroNova proposes a definition for a supplemental dose of RLA/R-DHLA as one that measurably affects biomarkers but is not specifically used to treat a disease.

What follows is an attempt to define these classifications and in so doing address the most relevant issues concerning the discussions over racemic ALA, RLA and R-DHLA and their use as nutritional supplements and as therapeutic agents."

Foreword supplied by and courtesy of GeroNova Research.



Cheers,
Pete

Tuesday, June 13, 2006

R-Lipoic - GeroNova Research R&D Pictures

Hope you enjoy these.

GeroNova Research Inc R&D Facility:

















Dr. Marc Foster Director of GRI analytical chemistry measuring plasma levels of RLA/R-DHLA:
















Geronova chemist Sarah Fischer isolating Na-RALA:

















David Carlson Director R&D holding 5kg of freshly distilled R-DHLA (corrected pic):





















David Carlson testing a new process for making RLA (corrected pic):


















GeroNova Research Inc's Analytical lab:

Drink Coffee? Drink Alcohol? Save Your Liver?

Boy, this is news I needed! I love the java, even though I am not much of a drinker.

"People who drink one cup of coffee are 20% less likely to have alcoholic cirrhosis than those who abstain from doing so."

A quote from the article: "Dr Klatsky added: "Even allowing for statistical variation, this shows there is a clear association between coffee consumption and protection against alcoholic cirrhosis."

Monday, June 12, 2006

Customer Feedback...

What a nice way to start the week...

"Thanks so much, Pete, for the exceptional personal treatment. Thanks for the courtesy upgrade shipment on R+ Asta, thanks for the quick delivery, and thanks for the friendly personal advice you've always given me. Thanks even for the beautiful Matisse (thank-you) card. More and more, I am turning to Relentless as my supplement provider of choice, and this is due , in no small measure to the solicitous care you seem to always give your customers. There is no substitute for that kind of personal service. Alas, too few companies today realize this, or even care to.

Kind Regards,
M.W."

Saturday, June 10, 2006

Wow! Juicing! Healthy!

I bought a juicer a few years ago, and frankly, it was a pain in the butt. Hard to clean and messy. I used it a few times and sold it.

But I love fresh vegetable juice, but when purchased at a restaurant or juice bar they are usually too heavy on sweetness or sugars. After shopping around for over a month, reading reviews, examining web sites, I settled in on a Breville 800JEXL Fountain Elite.

Got it last week and I am thrilled. Any juicer will require cleaning after each use, but this Breville is so easy. The parts are large and easy to handle. The quality is off the scale. The juicing ability is superb. I believe it operates at a higher (more juice!) RPM than any other juicer in the world.

This morning before I left the house for work, I prepared a delicious juice consisting of Celery, Purple Cabbage, Beet, Bean Sprouts, Carrots and Kale. I gotta tell you it was AWESOME! And very easy.

Because juice loses its beneficial vitamins and nutrients quickly, especially with exposure to air, I brought the fresh juice to work in a Nalgene bottle. Easy, convenient and quick to clean.

Fresh vegetable and fruit juice is natures anti-cancer and natural energy boost. Let's face it, most of us don't eat anywhere close to the amounts we need. But the results from juicing are simply delicious.



Amazon offers a great deal on these and I found a special coupon you can use to get and additional $25 bucks off! Just click the link above and enter SUNSAVER as the coupon in your checkout. It expires in 3 weeks so don't wait around.

Cheers,
Pete

Friday, June 09, 2006

Sneak Peek

Crayhon Research- one of the most innovative and highest quality suppliers in the world. Specializing in phospholipid cognitive support products. In stock next week.

More to come.

Their site is chock full of incredibly interesting information- enjoy!

Happy Weekend,
Pete

Wednesday, June 07, 2006

Salmon Essentials Back In Stock


AstaFactor Salmon Essentials with Astaxanthin is finally back in stock. This omega-3 supplement is fortified with potent antioxidant astaxanthin and has been a very popular seller. We sold out for several months, but it's back!

Each Salmon Essentials gelcap contains 1.33 mg pure astaxanthin 216 mg EPA and 144 mg DHA. Asta Factor® Gelcaps Salmon Essentials are a source of natural astaxanthin and omega-3 fatty acids.

Pete

Tuesday, June 06, 2006

Ortho-Core Sold Out for Several Weeks.

Please check the Ortho-Core page for availabiity- as soon as stock arrives, I will allow the product to be ordered.

Pete

Friday, June 02, 2006

New Genomic Research- We Are Not Entirely Human

I found this article amazing. The more I learn about our relationship with bacteria, the more I am intrigued.

A quote:
"Bacteria are so important to key functions such as digestion and the immune system that we may be truly symbiotic organisms -- relying on one another for life itself, the scientists write in Friday's issue of the journal Science."

And:
"We're entirely dependent on this microbial population for our well-being. A shift within this population, often leading to the absence or presence of beneficial microbes, can trigger defects in metabolism and development of diseases such as inflammatory bowel disease."

You have to read this. And you MUST use Theralac pro/pre-biotic

Happy Weekend!
Pete

Thursday, June 01, 2006

New From GeroNova Research- R-Plus With Astaxanthin.

Wow! I am loving this. Two awesome antioxidants and anti-inflammatories in one supplement. New R-Plus with Astaxanthin is 150 mg of R-Lipoic Acid (75mg R-Lipoic/75mg of R-Dihydrolipoic Acid) with 2mg per capsule of pharma quality AstaREAL Astaxanthin from Fuji Health Science.

From Fuji:
"Antioxidant - Cell Membrane protection:
Astaxanthin has been found to be a very potent lipid soluble antioxidant through in vitro and ex vivo studies. It has been shown to be 1000 times and 550 times more effective than vitamin E (-tocopherol) concerning lipid peroxidation and singlet oxygen quenching respectively.

Astaxanthin is also superior to many other antioxidants because of the unique role it may play in protecting the cell membrane because of its unique chemical structure and orientation within the living cell. Figure 1 shows astaxanthin's unique ability to span through the double layer cell membrane. For example, -carotene resides inside the bilipid membrane and vitamin C resides outside the bilipid membrane only. Whereas, the astaxanthin molecule is exposed both in and outside of the cell giving overall better protection. In addition, it can also function as a bridge by transporting trapped free radicals to the aqueous (polar) regions of the cell, thus making them available to water soluble antioxidants."













Patents:

Fuji astaxanthin Patents for human application

No. 6,245,818 -Increased physical endurance / reduced muscle damage
No. 6,773,708 -Immunomodulation - autoimmune diseases and chronic viral and intracellular bacterial infections
No. 6,262,316 -Gastric health - reduces infection/inflammation of H. pylori
No. 6,410,602 -Fertility - method of increasing the production and improving the quality of semen
Patent Pending -Reduced eye fatigue / improved visual acuity
Patent Pending -Wrinkle reduction - astaxanthin internal supplementation
Patent Pending -Weight Loss - BMI reduction
Patent Pending -Gene expression modulator - suppression of development of diabetic nephropathy
Patent Pending -Alleviates dyspeptic symptoms
Patent Pending -Cytokine regulation - inhibiting the expression of inflammatory cytokines and chemokines

While other suppliers are happy to sell the same old crap, GeroNova continues to innovate cutting edge, pharmaceutical quality supplements. I will be using this product starting today!

Cheers,
Pete