Friday, November 25, 2005

Aniracetam for Pain and Neuropathic Pain

Fascinating discoveries continue with the 'racetams. Nikeem Research in Italy offers some glimpses:

"The validation of nootropic pyrrolidones in neuropathic pain is significant."

"Among other pyrrolidinone nootropics, aniracetam produced significant analgesic effects."

"Together, these findings suggest that nefiracetam, and other cognition enhancers of the same pyrrolidinone nootropic class (Piracetam, Aniracetam, Oxiracetam), could be a good therapeutic tool against neuropathic pain, with no liabilities due to a possible involvement of the opioid system."

Nefiracetam and Leveracetam are not commonly available in the USA. Racetams in general have a long history of use, and are one of the few substances with essentially no known toxicity in humans.

Here is a second referenced and cited article by Clark Renwick Herniman and some relevant quotes:

"Aniracetam and nefiracetam are analogues of the drug piracetam (Gualtieri, et. al., 2002.). These drugs were originally developed to treat Alzheimer's disease although their action on N-type calcium channels may make them effective as analgesics as well (McGivern and McDonough, 2005). Aniracetam, 1-(p-anisoyl)-2-pyrrolidinone, is the older of the two drugs."

"Aniracetam has been shown to be a relatively non-toxic compound. Its LD50 is 4.5 g/kg orally in rats and 5.0 g/kg orally in mice while its ED50 in rodents is 10-100 mg/kg (Gouliaev and Senning, op. cit.). No toxic or teratogenic effects were found in the animal studies done with aniracetam (Ibid.)."

I will post some info on Pramiracetam in the next week or two.

PS- Relentless Improvement is the only supplier in the world to make publically available a full, independant 3rd party lab test result for their racetams. RI tests for microbial/fungal/yeast contamination, heavy metal contamination and purity via melting point and most importantly by HPLC analysis. *(Please read this CAREFULLY- nobody else tests for microbial/fungal/yeast)

If you use this product on a daily basis as I do, why risk contaminants? Better safe than sorry my friends!


45% of Americans Distrust Supplement Health Claims

Ha! I agree with them! In fact, that is why I started this business in the first place. To make an effort to separate the good stuff from the snake oil. And there are some very effective products out there (My blood tests prove it).

It is hard, very hard to ferret out the top-quality suppliers. I think we have earned a grade of "B" so far and are taking steps to raise that to a "B+" over the next few months. We have more things going on in the background that will further raise the bar in the nutriceutical business, and will be making some changes to our supplier line-up.

For those wondering, yes Relentless Improvement offers Premium-Quality Nutriceuticals, spelled with an "i". That's how we spell it.

A quote from this press release:

"Europe's Young Adults consume 36% more nutraceuticals than an average consumer, and even in the US the figure is as high as 28%. Despite stereotypes about Europeans being particularly distrustful of business, 45% of Americans say that they largely or entirely disbelieve food and drink manufacturers health claims, a similar figure to France and far more than in the Netherlands."

The hypesters and BS artists are rampant, and you are right to employ "buyer beware" approach. Shop for products from the highest quality suppliers, backed up with cited research.


Free book- The First immortal

Bruce Klein, the fine gentleman that heads up Immortality Institute sent me a care package this week. In it is a copy of "The First Immortal", which is a heck of a good read, and will make you rethink (or just think) about the issue of living longer.

Email me and I will priority mail you a fresh copy at no charge.

Oh- and go poke around ImmInst. You might just find yourself quite captivated. If you like what you see, sign-up and support the cause!

Happy holidays!