Thursday, August 16, 2012

Idebenone and Leber’s Hereditary Optic Neuropathy

Very positive results from a randomized placebo-controlled trial of Idebenone used at 900mg per day for Leber’s hereditary optic neuropathy.

See the study report here: http://brain.oxfordjournals.org/content/early/2011/07/23/brain.awr170.full

"This first randomized controlled trial in the mitochondrial disorder, Leber’s hereditary optic neuropathy, provides evidence that patients with discordant visual acuities are the most likely to benefit from idebenone treatment, which is safe and well tolerated."

"A key finding of this study was the minimal side-effect profile among patients with LHON treated with high-dose idebenone, which was not different to placebo, and contributed to the high compliance rates observed in this study. When combined with other published data, this indicates that at 900 mg/day, idebenone is safe and is well tolerated—a key factor in deciding whether or not this new treatment should be used in clinical practice. "

People choosing to use Idebenone should only consider a documented quality product such as that from Relentless Improvement where every batch is tested and the results are available for public view on the CoA's page. Why would anyone risk using an undocumented product?