Tuesday, January 03, 2006

EGCG and CLL (Chronic Lymphocytic Leukemia) More Info

I was reminded today by a Customer of the recent press release from the Mayo Clinic regarding their ongoing trials of CLL patients using an EGCG extract (NOT green tea!).

A quote from the press release:

"A new case study by Mayo Clinic researchers provides preliminary evidence to suggest a component of green tea may lead to clinical improvement in patients with chronic lymphocytic leukemia (CLL). Findings are published online in Leukemia Research."

"In the small case study, the researchers report on four patients who appeared to have an improvement in the clinical state of their disease after starting over-the-counter products containing epigallocatechin gallate (EGCG), an extract of green tea. Three of the four patients met the standard criteria used to define a response treatment for clinical trials. These same investigators had previously shown that EGCG kills leukemia cells from patients with CLL in the test tube by interrupting the communication signals they need to survive. That study was published in Blood in 2004. "

My customer told me he heard the amount of EGCG used was 3000mg daily which would equate to 5-6 capsules per day of EGCG Max (providing 560mg total catechins per capsule).

Or about 10 capsules per day if you consider only the EGCG component of the mixed catechins. I do not know if the studies broke out EGCG from total catechins.

ECGG Max is 90 vegi-caps per bottle.

Once again, this is not a situation where you want to use an off the shelf, grocery store green tea product. Please understand the difference between a pharmaceutical grade, standardised extract and the average crap that gets sold across the counter.

Pete