Saturday, May 21, 2005

Deprenyl (selegiline) Now Available. (in disguise)

Bacopa is a natural (superior) alternative to deprenyl.

Thank you Peter, my AOR sales rep and all around nice person (as Western Canadians inevitably are), for pointing this out to me.

Many folks use deprenyl for its reputed anti-aging effects on the brain. I use it. One problem- it is prescription only in the USA so you have to find a doctor willing to write one for an "off label" treatment, or, like I have done, buy from an offshore pharmacy.

But this whole time I was getting deprenyl's reputed beneficial effects as I took my daily dose or Ortho-Mind (300mg of Bacopa.

From AOR research- "But the most exciting of the recent animal studies shows that Bacopa boosts the brains production of the key protective antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT). In this, Bacopa is closely paralleling the effects of deprenyl (selegiline), a drug prescribed for Parkinsons disease, which is being taken by many people in the life extension movement because animal studies suggest that it has potent anti-aging effect. Remarkably, however, the effects of Bacopa were shown to be even more broad ranging than those of deprenyl: Bacopa cranked up levels of these enzymes in every tested area of the brain, while deprenyl failed to upregulate these enzymes in the hippocampus."

Read the full story on the Bacopa page above. Wow- What a wonderful choice, a natural substance available non-prescription.

Here is a little more, courtesy of AOR-

"Despite what you might hear, you can't boost levels of SOD or CAT by taking them as preformed supplements: even when taken sublingually, these enzymes are destroyed by other enzymes. One of the few things that can rev up the brain's production of these enzymes is the Parkinsons drug deprenyl (Eldepryl®); this jump in SOD and CAT has been associated in a series of remarkable experiments in mice, rats, hamsters, and dogs with remarkable jumps in lifespan. In the most dramatic of these experiments, deprenyl actually extended the built-in maximum lifespan of lab rats by as much as 24% a feat unprecedented by any other drug or nutrient.

But the results of other studies show that the effect is inconsistent. The success or failure of deprenyl in extending life seems to be closely associated with whether the drug boosts CAT and SOD in these organisms under the conditions of a given study. So it's especially encouraging that the effects of Bacopa on these enzymes were shown to be even more broad-ranging than those of deprenyl, affecting a wider range of areas in the brain, and simultaneously boosting levels of the detoxifying glutathione peroxidase (GSH-Px) enzyme an effect not seen with deprenyl. "

We offer Bacopa alone, or in Ortho-Mind supplement.

Pete